Atlas of Genetics and Cytogenetics in Oncology and Haematology PTBP 1 ( polypyrimidine tract binding protein 1 )

PTBP1 results from skipping of exon 9 (3203 bp mRNA and 531 amino acid protein). Three additional isoforms are generated by alternative splicing: PTBP2 (3260 bp mRNA and 550 amino acid protein) and PTBP4 (3281 mRNA protein and 557 amino acid protein) derive from exon 9 inclusion using two alternative 3' splice sites, while PTB-T has been reported to result from alternative splicing of exons 210 (Sawicka et al., 2004).